Lymphoma studies in patients with Sjögren's syndrome - DiVA
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Hence, identifying predictors of malignancy in PM and DM is crucial. However, few large series studies have reported prognostic and predictive factors of malignancy in patients with PM and DM. Moreover, in recent years, several published studies also allow us to better understand the OBJECTIVE: To assess the difference in clinical features and prognosis of patients with interstitial lung disease (ILD) comparing polymyositis (PM) and dermatomyositis (DM). METHODS: Medical records of 28 ILD patients with PM/DM (16 PM-ILD, 12 DM-ILD) were reviewed retrospectively. Mortality from polymyositis and dermatomyosi- tis was estimated between 1968 and 1978. Age-specific average annual mortality rates showed unimodal distri- butions for all sex-race groups. Synergistic interaction was demonstrated between female sex and nonwhite race, greatest mortality being in nonwhite females through age 74. The muscles affected are typically those closest to the trunk or torso.
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2021-04-02 2021-01-05 Overview. Years ago, only the worst cases of systemic sclerosis (scleroderma) were diagnosed, thus leading to the widespread belief that systemic scleroderma was always progressive and fatal.. Now that the full range of types and severity of scleroderma are being recognized and diagnosed, there is increasing awareness that many people have a milder type of illness with a much rosier longterm The median survival for polymyositis was 11.0 years (95% CI: 9.5-13.3) and that for DM 12.3 years (5.5-20.7). The standardized mortality ratio for the combined group of PM and DM showed approximately threefold mortality compared to the general population. Morbidity and mortality in adult polymyositis and dermatomyositis. Before the use of corticosteroids, the prognosis for polymyositis/dermatomyositis (PM/DM) was extremely poor.
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Survival was modeled by left-truncated Kaplan-Meier estimation and Cox regression. The 5- and 10-year survival estimates were 77% (95% CI = 66 to 85), and 62% (95% CI = 48 to 73), respectively, and the rates were similar for polymyositis and dermatomyositis.
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The long-term outlook (prognosis) for people affected by polymyositis varies. Most affected people respond well to treatment and regain muscle strength, although a certain degree of muscle weakness may persist in some cases. In most cases, polymyositis is not life-threatening, and many people recover partially or completely from the disease. Request PDF | Prognosis and mortality of polymyositis and dermatomyositis patients | The objective of this study was to assess the long-term outcome of polymyositis (PM) and dermatomyositis (DM 30. • Schiopu E, Phillips K, Macdonald PM, et al.
The standardized mortality ratio for the combined group of PM and DM showed approximately threefold mortality compared to the general population.
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Airio A, Kautiainen H, Hakala M: Prognosis and mortality of polymyositis and dermatomyositis patients. Clin Rheumatol. 2006, 25: 234-239.
Polymyositis life expectancy Onset of polymyositis is gradual over several months.
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Lymphoma studies in patients with Sjögren's syndrome - DiVA
Before the introduction of glucocorti- coids in the treatment of polymyositis and dermatomyositis, the mortality was reported to be Table 1. The standardized mortality ratio (SMR), life expectancy (LE) and years of life lost (YLL). Idiopathic myositis, Morbidity, SF‐36, Treatment, Mortality.
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PDF Adaptation of the Charlson Comorbidity Index for
The standardized mortality ratio for the combined group of PM and DM showed approximately threefold mortality compared to the general population.
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Predictive factors for a poor prognosis in PM/DM patients are older age, involvement of lung and cardiac systems, dysphagia, cancer, and serum myositis–specific antibodies (including coexistent presence of anti-Ro52 and anti-Jo1 antibodies, anti–signal recognition particle antibody, anti-155/140, and anti–CADM-140 antibodies).
In rare cases, individuals with severe and progressive muscle weakness will develop respiratory failure or pneumonia. Pulmonary involvement in polymyositis and dermatomyositis Pulmonary complications play an important role in causing morbidity and mortality in myositis, and interstitial lung disease (ILD) has been reported in up to 65% of myositis patients. Clinical symptoms including cough and dyspnoea are common, but they are not reliable for ILD detection. Predictive factors for a poor prognosis in PM/DM patients are older age, involvement of lung and cardiac systems, dysphagia, cancer, and serum myositis–specific antibodies (including coexistent presence of anti-Ro52 and anti-Jo1 antibodies, anti–signal recognition particle antibody, anti-155/140, and anti–CADM-140 antibodies). Polymyositis patients may also experience other symptoms such as morning stiffness, fatigue and anorexia, fever and weight loss. In addition, people with polymyositis may also have arthralgia and arthritis [6].