Flytande avblandning av intrinsiskt störda proteiner utsädes

P38 mapk-signalering och fosforyleringar i brct1-domänen

ku70/80 ku7000 ku70 antibody ku70 uniprot ku7000 specs ku70/80 function ku70ut7000fxkr ku70ut7080fxkr ku70 and ku80 function Please note that this site uses cookies to personalise content and adverts, to provide social media features, and to analyse web traffic. Ku70 is the 70 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80. The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination.

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May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4 UniProt builds upon the solid foundations laid by the consortium members PIR, European Bioinformatics Institute and Swiss Institute of Bioinformatics over many years. When to use UniProt Use UniProt to retrieve Ku70 autoantigen PIRSF016570:Ku80 autoantigen PIRSF Homeomorphic Family • Exactly one level • Full-length sequence similarity Ku70/80 subunits PF02735: Ku70/Ku80 beta- barrel domain Domain Superfamily • One common Pfam domain PIRSF006493: Ku DNA-binding protein, prokaryotic type PIRSF016570: Ku DNA-binding complex, Ku80 subunit PIRSF500001: IGFBP-1 pir.georgetown.edu/pirsf pir.georgetown.edu/iprolink Ku70 was detected in paraffin-embedded section of Human Tonsil Tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/ml rabbit anti-Ku70 Antibody (PB9520) overnight at 4°C.

Ku70 is involved in repair of  G22p1, Ku70, Ku p70 less.

P38 mapk-signalering och fosforyleringar i brct1-domänen

All lanes: Anti Ku70 (PA1642) at 0.5ug/ml. Lane 1: HT1080 Whole Cell Lysate at 40ug. Lane 2: SGC Whole Cell Lysate at 40ug. Lane 3: MM453 Whole Cell Lysate at 40ug.

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The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex.

Supplied as 400 µL purified antibody (2 mg/mL). The Ku70/Ku80 heterodimer has ATP-dependent DNA helicase activity and functions as the DNA-binding regulatory component of DNA-dependent protein kinase (DNA-PK) (6-8). The assembly of the DNA-PK complex at DNA ends is required for nonhomologous end-joining (NHEJ), one mechanism involved in double-stranded DNA break repair and V(D)J recombination (8). Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. Mischo H.E., Hemmerich P., Grosse F., Zhang S. Formation of gamma-H2AX foci is a P. O.cellular response to genotoxic stress, such as DNA double strand breaks or stalled replication forks. Knockdown of Ku70 was achieved by transfecting HeLa with Ku70 specific siRNAs (Silencer® select Product # S5455, S5457). Western blot analysis (Fig.
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Expression, Ku70 is ubiquitously   Homo sapiens KU70(XRCC6) and KU80(XRCC5) protein sequences were retrieved from. UniProt and KU 70/80 beta barrel domain sequence length was  Rabbit anti Ku70 antibody recognizes human Ku70, also known as XRCC6, G22P1 or X-ray repair cross-complementing protein 6.

(Q23976).
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Ku protein - Ku protein - qaz.wiki

KU70 – Kontrolluppgift – Näringsbidrag och royalty (SKV 2316) På skatteverket.se använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor. Involved in non-homologous end joining (NHEJ) DNA double strand break repair.

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Protein Signatures (InterPro).

UniProt ID: P12956. Entrez-Gene Id: 2547 · View in PhosphoSitePlus^{® logo PhosphoSitePlus. Product Citations: 21.}